Intrinsic Frequencies of Carotid Pressure Waveforms Predict Heart Failure Events

Intrinsic frequencies (IFs) derived from arterial waveforms are associated with cardiovascular performance, aging, and prevalent disease (CVD). However, prognostic value of these novel measures is unknown. We hypothesized that IFs incident CVD risk. Our sample was drawn the Framingham Heart Study Original, Offspring, Third Generation Cohorts included participants free at baseline (N=4700; mean age 52 years, 55% women). extracted 2 dominant directly a series carotid pressure waves: IF coupled heart vascular system during systole (ω 1 ) decoupled vasculature diastole ). Total frequency variation (Δω) defined as difference between ω . used Cox proportional hazards regression models to relate events follow-up 10.6 years. In multivariable adjusted for risk factors, higher (hazard ratio [HR], 1.14 [95% CI], 1.03–1.26]; P =0.01) Δω (HR, 1.16 CI, 1.03–1.30]; =0.02) but lower 0.87 0.77–0.99]; =0.03) were composite events. similarly models, 1.23 1.07–1.42]; =0.004) 1.26 1.05–1.50]; 0.81 0.66–0.99]; =0.04) failure. not significantly myocardial infarction or stroke. Novel may represent valuable markers failure in community.